Magnetocaloric effect of Fe_3O_4/P(NIPAAm-co-Am)composite microspheres for tumor treatment application

Research on the magnetic thermo-sensitive composite microspheres for controlled release drug carrier was meaningful.Magnetocaloric effect was used to heat the Fe3 O4 /P(NIPAAm-co-Am)composite microspheres,and the heat generation abilities of the composited microspheres in alternation magnetic field(AMF) were investigated in the present work.Results show the resultant Fe3 O4 /P(NIPAAm-co-Am)composite microspheres exhibite excellent superparamagnetic and high heating generation ability.The temperature of the composite microspheres was raised after exposed to AMF,which can stimulate the shrinks of P(NIPAAm-coAm).Furthermore,the temperature raised after exposed to AMF can be adjusted by controlling the concentration of composite microspheres,the magnetic intensity and the frequency of the AMF.