In the correlation calculations,people only pay attention to positive correlation;negative correlation is often overlooked.During the actual research work on pattern registration algorithm,we find that positive correlation strength-ens signal,meanwhile negative correlation can also be used to evaluate the signal.Negative correlation is a complemen-tary role for positive correlation.This paper discusses the value of the negative correlation in reliable patter registration.The experimental results in this paper show that negative correlation can suppress the noises generated in positive corre-lation processing.The high precision and reliable pattern registration has been realized.