Novel DNA delivery systems for the gene therapy

It is extremely important to establish and develop a safe and efficient delivery system for the gene therapy. Although the virus vectors have been used for hundreds clinical trials of gene therapy, their safety remains uncertain. Recently, more nonviral delivery systems for gene transfer have been developed and used widely. This review discussed some of the novel gene delivery systems, which are being used in our laboratory including transduction peptides, in vivo DNA electrotransfer and chitosan as DNA delivery vector