Double Plasma Molecular Adsorption System Plus Sequential Half‐Dose Plasmapheresis in Tandem With Continuous Renal Replacement Therapy: A Case Report

A 48-year-old male patient was diagnosed with critical acute pancreatitis, renal dysfunction and liver dysfunction. Because of the presence of multiorgan dysfunction, continuous renal replacement therapy (CRRT) was required on the first day of the patient's admission to the ICU in order to help stabilize the patient's internal environment. Meanwhile, the patient also received a total of five double plasma molecular adsorption system plus sequential half-dose plasmapheresis (DPMAS-PE) treatments, of which the first, fourth, and fifth DPMAS-PE treatments were chosen to be administered concurrently with CRRT. This report is to clarify how four CRRT machines using three parallel modalities successfully completed DPMAS-PE in tandem with CRRT (DPMAS-PE-CRRT). Furthermore, DPMAS-PE-CRRT showed similar effectiveness in removing total bilirubin and total bile acid when compared to nonparallel CRRT. During the parallel therapy, there were no serious adverse reactions. To validate this case, more clinical trials are needed.