航向(导航)
透视图(图形)
药物输送
医学
药品
医学物理学
重症监护医学
药理学
工程类
纳米技术
计算机科学
材料科学
人工智能
航空航天工程
作者
Margaret Landis,Tracey Boyden,Simon Pegg
出处
期刊:Therapeutic Delivery
[Newlands Press Ltd]
日期:2012-02-01
卷期号:3 (2): 195-208
被引量:47
摘要
Delivery of drug therapeutics across the blood-brain barrier is a challenging task for pharmaceutical scientists. Nasal-to-CNS drug delivery has shown promising results in preclinical efficacy models and investigatory human clinical trials. The further development of this technology with respect to the establishment of valid, predictable preclinical species models, translatable pharmacokinetic-pharmacodynamic relationships and definition of toxicology impact will help attract additional pharmaceutical investment in this drug-delivery approach. Further discoveries in nasal nanotechnology, targeted delivery devices and diagnostic olfactory imaging will serve to fuel the advancements in this area of drug delivery.
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