线粒体
癌症干细胞
干细胞
癌症研究
细胞生物学
癌细胞
癌症
粒体自噬
生物
细胞凋亡
化学
线粒体DNA
线粒体融合
作者
Rute Loureiro,Katia A. Mesquita,Paulo J. Oliveira,Ignacio Vega-Naredo
出处
期刊:Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
日期:2013-05-01
卷期号:7 (2): 102-114
被引量:42
标识
DOI:10.2174/18722148113079990006
摘要
Complete knowledge about the evolution of the carcinogenic process has to include cancer stem cells (CSCs), which are essential to understand tumor occurrence, recurrence, and also its reduction rate after radio- and/or chemotherapeutic treatments. Understanding CSCs physiology and metabolism may be crucial for the development of novel effective therapies. Therefore, being mitochondria an undeniable target for cancer therapy and a central hub in metabolism and cell and death decisions, it is essential to take this organelle into account and explore its actions and involvements in the context of CSCs physiology. In this review, we focus on recent patents and discoveries about mitochondrial bioenergetics and physiology of CSCs. A full understanding of the role of mitochondrial activity in CSCs and the creation of new strategies, methods and discoveries to support actual treatments with novel ones are of pivotal importance in order to ultimately eradicate cancer.
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