mTORC1型
自噬
安普克
结直肠癌
癌症研究
PI3K/AKT/mTOR通路
细胞生物学
生物
细胞凋亡
癌症
激酶
信号转导
遗传学
蛋白激酶A
作者
Zuolei Jing,Xinyuan He,Zhirong Jia,Yunli Sa,Bo‐Lin Yang,Ping Liu
标识
DOI:10.1016/j.canlet.2021.06.029
摘要
Non-SMC condensin I complex subunit D2 (NCAPD2) is one of the three non-SMC subunits in condensin I. Previous studies have shown that NCAPD2 plays an important role in the chromosome condensation and segregation. However, its role in the development of colorectal cancer (CRC) and specific molecular mechanisms still need to be further studied. Here we show that NCAPD2 inhibits autophagy and blocks autophagic flux via Ca2+/CAMKK/AMPK/mTORC1 pathway and PARP-1/SIRT1 axis. NCAPD2 acts as a tumor promoter both in vitro and in vivo. NCAPD2 knockout suppresses colorectal cancer development in AOM/DSS induced mice model. Therefore, our findings support a role for NCAPD2 in autophagy to promote CRC development and highlight NCAPD2 as a potential target for CRC therapy.
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