Chemical constituents from Lycium barbarum (Solanaceae) and their chemophenetic significance

Phytochemical investigation of the fruit of Lycium barbarum L. has yielded nine alkaloids including one new compound, lycibarbarspermidine T together with eight known compounds. The structures were unambiguously determined by spectroscopic analyses and chemical methods. The chemophenetic significance of all these compounds was summarized. Among the known compounds, compounds 6 and 9 are reported from L. barbarum for the first time, whereas compounds 2–5 have previously been only found in this plant. The anti-inflammatory effects of all compounds were evaluated by measuring the NO production in RAW 264.7 cells stimulated by lipopolysaccharide (LPS). The results showed that compounds 1–3 and compounds 5–9 could inhibit the NO release of RAW 264.7 cells stimulated by LPS at 30 μM.