HEMA in Polymers with Thermoresponsive Properties

This review presents the current state-of-knowledge concerning thermoresponsive copolymers containing 2-hydroxyethyl methacrylate (HEMA). The thermoresponsive copolymers based on HEMA, HEMA derivatives, and copolymers with modified HEMA units in the chain studied so far are presented. Information about their transition temperature in dilute water or buffer solution and the influence of various factors on their thermoresponsive properties described so far in the literature are reported. The research of the aggregation of HEMA containing thermoresponsive chains concern the morphology and size of nanoparticles formed upon heating. Using the available data, we tried to expose the impact of HEMA content in thermoresponsive chains on thermal properties of the copolymers. Modifications of the HEMA hydroxyl groups led to of thermoresponsive macromolecules with various structures and topologies. New functionality introduced by modification improves properties (stability, biocompatibility, and others) of the polymers and their aggregates. Thermal aggregation of HEMA-based copolymers allowing for the creation of carriers of biologically active substances, we presented in a separate part of the review. The works discussed in the review show significant possibilities for using HEMA in obtaining thermoresponsive polymer materials for medical applications.