齐墩果酸
药物发现
生物活性
化学
药物开发
萜烯
药品
计算生物学
组合化学
药理学
体外
生物
生物化学
医学
病理
替代医学
作者
Wang Wang,Yutong Li,Yan Li,Dejuan Sun,Hua Li,Lixia Chen
标识
DOI:10.2174/1568026621666211105101231
摘要
Natural products have been proven as the main source of biologically active compounds, which are potentially useful for drug development. As one of the most studied pentacyclic triterpenes, oleanolic acid (OA) exhibits a broad range of biological activities and serves as a good scaffold for the development of novel derivatives that could be vital in drug discovery for various ailments. Till now, many of its derivatives with multiple bioactivities have been prepared through chemical modification. This review summarizes the recent reports of OA derivatives (2016-present) and their biological effects and action mechanisms in vitro and in vivo models, and discusses the design of novel and potent derivatives.
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