二萜
萜类
生物
立体化学
代谢物
异源表达
生物化学
化学
基因
重组DNA
作者
Yohei Morishita,Kento Tsukada,Kazuma Murakami,Kazuhiro Irie,Toshinobu Asai
标识
DOI:10.1021/acs.jnatprod.1c00973
摘要
Diterpenoid pyrones are a type of mainly fungal meroterpenoid metabolite consisting of a diterpene connected to a pyrone, some of which show potent bioactivity. Through genome mining and heterologous expression, nine new diterpenoid pyrones, shearones A-I (1-9), were discovered from the fungus Eupenicillium shearii IFM 42152, and their biosynthetic enzyme activities were revealed. Some of these heterologously biosynthesized diterpenoid pyrones exhibited moderate antiaggregative ability against amyloid β42 in vitro.
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