Immune senescence in multiple myeloma—a role for mitochondrial dysfunction?

免疫衰老 免疫系统 免疫学 衰老 癌症 生物 免疫功能障碍 疾病 机制(生物学) 人口 医学 遗传学 内科学 哲学 环境卫生 认识论
作者
Frances Seymour,Jonathan Carmichael,Claire Taylor,Christopher Parrish,Gordon Cook
出处
期刊:Leukemia [Springer Nature]
卷期号:36 (10): 2368-2373 被引量:5
标识
DOI:10.1038/s41375-022-01653-7
摘要

Age-related immune dysfunction is primarily mediated by immunosenescence which results in ineffective clearance of infective pathogens, poor vaccine responses and increased susceptibility to multi-morbidities. Immunosenescence-related immunometabolic abnormalities are associated with accelerated aging, an inflammatory immune response (inflammaging) and ultimately frailty syndromes. In addition, several conditions can accelerate the development of immunosenescence, including cancer. This is a bi-directional interaction since inflammaging may create a permissive environment for tumour development. Multiple myeloma (MM) is a mature B-cell malignancy that presents in the older population. MM exemplifies the interaction of age- (Host Response Biology; HRB) and disease-related immunological dysfunction, contributing to the development of a frailty syndrome which impairs the therapeutic impact of recent advances in treatment strategies. Understanding the mechanisms by which accelerated immunological aging is induced and the ways in which a tumour such as MM influences this process is key to overcoming therapeutic barriers. A link between cellular mitochondrial dysfunction and the acquisition of an abnormal immune phenotype has recently been described and has widespread physiological consequence beyond the impact on the immune system. Here we outline our current understanding of normal immune aging, describe the mechanism of immunometabolic dysfunction in accelerating this process, and propose the role these processes are playing in the pathogenesis of MM.
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