脂肪生成
阿卡波糖
化学
阳性对照
脂肪细胞
抑制性突触后电位
生物化学
非竞争性抑制
受体
酶
石斛
立体化学
过氧化物酶体增殖物激活受体
体外
生物
脂肪组织
传统医学
内分泌学
植物
医学
作者
May Thazin Thant,Hnin Ei Ei Khine,Justin Quiel Lasam Nealiga,Nutputsorn Chatsumpun,Chatchai Chaotham,Boonchoo Sritularak,Kittisak Likhitwitayawuid
出处
期刊:Molecules
[MDPI AG]
日期:2022-02-09
卷期号:27 (4): 1156-1156
被引量:5
标识
DOI:10.3390/molecules27041156
摘要
Chemical investigation of Dendrobium delacourii revealed 11 phenolic compounds, and the structures of these compounds were determined by analysis of their NMR and HR-ESI-MS data. All compounds were investigated for their α-glucosidase inhibitory activity and anti-adipogenic properties. Phoyunnanin E (10) and phoyunnanin C (11) showed the most potent α-glucosidase inhibition by comparing with acarbose, which was used as a positive control. Kinetic study revealed the non-competitive inhibitors against the enzyme. For anti-adipogenic activity, densifloral B (3) showed the strongest inhibition when compared with oxyresveratrol (positive control). In addition, densifloral B might be responsible for the inhibition of adipocyte differentiation via downregulating the expression of peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT enhancer-binding protein alpha (C/EBPα), which are major transcription factors in adipogenesis.
科研通智能强力驱动
Strongly Powered by AbleSci AI