透明质酸
骨关节炎
甲壳素
材料科学
增粘剂
软骨
关节软骨
润滑
生物医学工程
润滑油
细胞外基质
壳聚糖
医学
化学
复合材料
关节内
病理
解剖
生物化学
替代医学
作者
Wenbin Liu,Mengsi Ma,Zehua Lei,Zixuan Xiong,Tenghui Tao,Pengfei Lei,Yihe Hu,Xulin Jiang,Jun Xiao
标识
DOI:10.1016/j.matdes.2022.110579
摘要
Osteoarthritis is a chronic degenerative joint disease and its signs of progress mainly attribute to the significant increase of joint friction and the destruction of articular cartilage. Combined cartilage repair and joint lubrication may be a feasible strategy for the treatment of osteoarthritis. In this study, the hydroxypropyl chitin (HPCH)/hyaluronic acid (HA) hydrogel, prepared by physical mixing of HA and HPCH, was designed to be a new bio-lubricant and a chondroprotective agent for osteoarthritis treatment. HA release in HPCH/HA hydrogel was more durable and stable and in vitro experiments showed that HPCH/HA hydrogel could promote the synthesis of the extracellular matrix of chondrocytes. Additionally, HPCH/HA hydrogel could delay the progression of osteoarthritis in DMM-induced osteoarthritis mouse model. To sum up, HPCH/HA hydrogel developed herein can achieve the dual function of well lubrication of joints and protection of cartilage and has the clinical potential as synergetic treatment of osteoarthritis.
科研通智能强力驱动
Strongly Powered by AbleSci AI