光动力疗法
葡萄酒色斑
医学
波尔图葡萄酒
皮肤病科
活检
病理
放射科
外科
光学
物理
有机化学
化学
激光器
作者
Yue Han,Wenxin Yu,Li-Zhen Wang,Qingqing Cen,Li Luo,Jiafang Zhu,Xiaolin Zhang,Gang Ma,Xiaoxi Lin
出处
期刊:Photobiomodulation, photomedicine, and laser surgery
[Mary Ann Liebert]
日期:2022-03-01
卷期号:40 (3): 159-162
被引量:4
标识
DOI:10.1089/photob.2021.0111
摘要
Background: Vascular-targeted photodynamic therapy (PDT) is an effective alternative treatment choice for port-wine stains (PWSs). The histological characteristics of PWSs after PDT treatment have not yet been reported. Objective: To investigate the morphological features of PWSs treated by PDT and define the histopathological characteristics of PWS that achieve clinical cure. Methods: Thirteen patients with facial PWSs, who presented with complete regressive PWS lesions after a mean of 4.38 (standard deviation = 4.907) sessions of PDT. Post-treatment biopsy samples were obtained from each patient. The number of blood vessels, vascular diameter, and depth were measured and compared in all samples of PDT-regressive sites, PDT-resistant sites, and normal skin. Results: Within the 7-year follow-up after PDT, there was no recurrence in the regression area of PDT. In the PDT-regressive sites, within 800 μm of the dermal-epidermal junction, the dilated vessels were occluded and remained fissure-like after PDT. Conclusions: When the vascular lesions within 800 μm of the dermal-epidermal junction were closed after PDT, a stable clinical cure (no recurrence) was achieved.
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