沙眼衣原体
微生物学
环丙沙星
铜绿假单胞菌
鲍曼不动杆菌
化学
肺炎克雷伯菌
肺炎克雷伯菌
诺氟沙星
细菌
屎肠球菌
病菌
抗生素
金黄色葡萄球菌
福氏志贺氏菌
肠杆菌
病毒学
生物
大肠杆菌
生物化学
基因
遗传学
作者
Thi Huyen Vu,Nguyêt-Thanh Ha-Duong,Alexandra Aubry,Estelle Capton,Pierre Fechter,Patrick Plésiat,Philippe Verbeke,Nawal Serradji
标识
DOI:10.1016/j.bioorg.2018.10.033
摘要
Chlamydia trachomatis is a bacterial human pathogen responsible for the development of trachoma, an infection leading to blindness, and is also the cause of the main bacterial sexually transmitted infection worldwide. We designed a new inhibitor of this bacterium with, however, some prerequisites using (i) the iron dependency of the bacterium, (ii) a commercially available broad-spectrum antibiotic and (iii) a short synthetic pathway. The corresponding 8-hydroxyquinoline-ciprofloxacin conjugate was evaluated against a panel of pathogenic bacteria, including C. trachomatis but also the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species). Its anti-Chlamydia activity is higher than that of ciprofloxacin and seems to be related to the fluoroquinolone moiety of the molecule, which is also responsible for the complexation of iron(III), as demonstrated by spectrophotometric titration.
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