淋巴
淋巴系统
淋巴结切除术
转移
医学
微转移
生物医学工程
癌症
病理
淋巴结
内科学
作者
Yajun Wang,Jingjie Nan,Haiying Ma,Jiajun Xu,Feifei Guo,Yufeng Wang,Yongye Liang,Junhu Zhang,Shoujun Zhu
出处
期刊:Nano Letters
[American Chemical Society]
日期:2023-04-18
卷期号:23 (9): 4039-4048
被引量:7
标识
DOI:10.1021/acs.nanolett.3c00829
摘要
Radical lymphadenectomy remains the cornerstone of preventing tumor metastasis through the lymphatic system. Current surgical resection of lymph nodes (LNs) based on fluorescence-guided surgery (FGS) suffers from low sensitivity/selectivity with only qualitative information, hampering accurate intraoperative decision-making. Herein, we develop a modularized theranostic system including NIR-II FGS and a sandwiched plasmonic chip (SPC). Intraoperative NIR-II FGS and detection of tumor-positive lymph nodes were performed on the gastric tumor to determine the feasibility of the modularized theranostic system in defining LN metastasis. Under the NIR-II imaging window, the orthotopic tumor and sentinel lymph nodes (SLNs) were successfully excised without ambient light interference in the operating room. Importantly, the SPC biosensor achieved 100% sensitivity and 100% specificity for tumor markers and realized rapid and high-throughput intraoperative SLN detection. We propose the synergetic design of combining the NIR-II FGS and suitable biosensor will substantially improve the efficiency of cancer diagnosis and therapy follow-up.
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