Engineered extracellular vesicles for nose-to-brain co-delivery of chlorotoxin and curcumin for treatment of glioblastoma

The results suggest that CTX is not only an anti-tumor drug, but also a targeting ligand for enhanced cellular uptake. Therefore, enhanced therapeutic effects of CTX-EV/Cur may be due to synergistic effects of CTX and curcumin. Combined delivery of curcumin and CTX using CTX-EVs may be useful for treatment of glioblastoma.