纳米笼
铁蛋白
体内分布
药物输送
生物相容性
药品
化学
纳米技术
靶向给药
组合化学
药理学
材料科学
生物化学
有机化学
医学
体外
催化作用
作者
Yuko Nakahara,Yuta Endo,I. Inoue
出处
期刊:Methods in molecular biology
日期:2023-01-01
卷期号:: 335-347
被引量:1
标识
DOI:10.1007/978-1-0716-3222-2_19
摘要
Ferritin is one of the most promising drug delivery system (DDS) carriers because of its uniform nanosize, biodistribution, efficient cellular uptake, and biocompatibility. Conventionally, a disassembly/reassembly method that requires pH change has been used for the encapsulation of molecules in ferritin protein nanocages. Recently, a one-step method in which a complex of ferritin and a targeted drug was obtained by incubating the mixture at an appropriate pH, was established. Here, we describe two types of protocols, the conventional disassembly/reassembly method, and the novel one-step method for the construction of a ferritin-encapsulated drug using doxorubicin as an example molecule.
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