Novel high yielding route for the synthesis of Melphalan dimer impurity G

Melphalan dimer is an impurity from the synthesis of Melphalan (M216900) which is an antineoplastic agent. In this article, a new route for the synthesis of Melphalan dimer impurity G has been discussed. The new research provides the first high-yield, high-purity synthesis of this impurity. The impurity has been confirmed for purity using HPLC, and its structure has been identified using MS, ¹H and ¹³C NMR.