The Essence of Nature Can be the Simplest (3) Holistic Energy: Extracellular Fenton Reactions of All Cells

ABSTRACT Cooperative mechanisms are widely regarded as pivotal drivers in the evolutionary transition from unicellular to multicellular life. However, the mechanism of how multicellular organisms integrate the individual energy of all cells into holistic energy and how exactly the holistic energy is manifested remains poorly understood. Traditionally, relying on ATP within heart muscle cells to drive a permanent heartbeat (called cardiac contraction) is responsible for the vital holistic biological process of transporting and distributing oxygen and nutrients to cells throughout the body, but the limited ATP reserve in cardiac muscle challenges this paradigm. Recent studies suggest that cellular energy production involves dual pathways: canonical ATP synthesis and extracellular Fenton reactions. Here, we propose a novel paradigm wherein the circulatory system serves as a collective platform for integrating extracellular Fenton reaction capabilities of all cells, generating sustained and powerful energy to drive the heartbeat and maintain body temperature. This cooperative mechanism for holistic energy aligns with Bergmann's rule and the holistic principles of traditional Chinese medicine (TCM). Holistic energy in circulatory system supports pulse diagnosis that evaluates systemic health through vascular dynamics. Furthermore, the interaction and balance between holistic energy and individual energy can also explain the rationality of tumor occurrence.