“Dual lock-and-key” triggered and endoplasmic reticulum targeting nanophotosensitizers for activatable Type-I photodynamic and photothermal therapies

A “dual lock-and-key” nanophotosensitizer with ER-targeting capability was constructed for bioimaging-guided phototherapies, which can be activated only by weak acidity and GSH overexpression, leading to tumor specificity and biosafety.