Establishment and Evaluation of a New Type of Animal Model of Persistent Inflammation, Immunosuppression, and Catabolism Syndrome Based on Gut Microbiota Dysbiosis and Bacterial Translocation

Collectively, our work developed a new type of mouse PICS model and elucidated that bacterial translocation plays a critical role in PICS. It also sheds light on tryptophan derivatives as potential therapeutic targeting of PICS.