General access to furan-substituted gem-difluoroalkenes enabled by PFTB-promoted cross-coupling of ene-yne-ketones and difluorocarbene

An efficient method for the tandem cyclization cross-coupling of conjugated ene-yne-ketones with difluorocarbene via PFTB promotion is described, providing facile access to diverse furan-substituted difluoroalkenes with potential antitumor potency.