A Semi‐Supervised Transformer Survival Prediction Model for Lung Cancer

材料科学 变压器 肺癌 预测建模 机器学习 肿瘤科 计算机科学 医学 电气工程 工程类 电压
作者
Jing Teng,Lan Yang,Shan Wang,Jing Yu
出处
期刊:Advanced Functional Materials [Wiley]
卷期号:35 (26) 被引量:4
标识
DOI:10.1002/adfm.202419005
摘要

Abstract Analyzing survival rates for lung cancer presently grapples with two significant hurdles. Insufficient available data is the first one, which is exacerbated by a large amount of censored information, thereby obstructing the effective employment of this data for accurate predictions. Second, lung cancer patient survival data often exhibit complex temporal feature associations, suggesting patient‐specific traits on survival outcomes. To address these issues, the dataset are augmented by integrating semi‐supervised learning, which allows for more effective use of the event data and mitigates overfitting issues. Subsequently, a Transformer‐based predictive model is developed, trained by assorted survival time groups, intending to expand the comprehension of data feature associations. The accuracy of the proposed model is meticulously assessed using a variety of validation metrics, including the Time‐dependent C‐statistic, Integrated Brier Score (IBS), the Time‐dependent receiver operating characteristic (ROC) curves, and survival curves. These rigorous evaluations offer an intricate insight into the model's performance across different time intervals and event occurrences, thus obtaining a holistic comprehension of the model's precision. The experimental findings convincingly demonstrate the superiority of the proposed framework compared to state‐of‐the‐art methods.
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