An esterase-activated diketopyrrolopyrrole-based theranostic prodrug for precise pyroptosis and synergistic chemo-photodynamic therapy of pancreatic cancer

The diketopyrrolopyrrole-based theranostic prodrug (DPP-QS) releases LD-targeted AIE PS (DPP-QE) and drug (chlorambucil) under the cleavage of esterase to achieve precise pyroptosis and chemo-photodynamic therapy of pancreatic cancer.