光热治疗
材料科学
生物膜
纳米技术
涂层
细菌
光动力疗法
抗菌剂
促炎细胞因子
聚集诱导发射
微生物学
生物
炎症
化学
免疫学
物理
量子力学
荧光
遗传学
有机化学
作者
Jianzhong Wang,Neethu Ninan,Ngoc Huu Nguyen,Minh-Le Nguyen,Rakesh P. Sahu,Tien Thanh Nguyen,Agnieszka Mierczynska‐Vasilev,Krasimir Vasilev,Vi Khanh Truong,Youhong Tang
标识
DOI:10.1021/acsami.3c19484
摘要
Developing novel antibacterial strategies has become an urgent requisite to overcome the increasing pervasiveness of antimicrobial-resistant bacteria and the advent of biofilms. Aggregation-induced emission-based photosensitizers (AIE PSs) are promising candidates due to their unique photodynamic and photothermal properties. Bioengineering structure-inherent AIE PSs for developing thin film coatings is still an unexplored area in the field of nanoscience. We have adopted a synergistic approach combining plasma technology and AIE PS-based photodynamic therapy to develop coatings that can eradicate bacterial infections. Here, we loaded AIE PSs within biomimetic bacterium-like particles derived from a probiotic strain, Lactobacillus fermentum. These hybrid conjugates are then immobilized on polyoxazoline-coated substrates to develop a bioinspired coating to fight against implant-associated infections. These coatings could selectively kill Gram-positive and Gram-negative bacteria, but not damage mammalian cells. The mechanistic studies revealed that the coatings can generate reactive oxygen species that can rupture the bacterial cell membranes. The mRNA gene expression of proinflammatory cytokines confirmed that they can modulate infection-related immune responses. Thus, this nature-inspired design has opened a new avenue for the fabrication of a next-generation antibacterial coating to reduce infections and associated burdens.
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