医学
疾病
语境化
免疫性血小板减少症
病理生理学
免疫系统
免疫学
骨髓
发病机制
流行病学
血小板
重症监护医学
病理
口译(哲学)
计算机科学
程序设计语言
作者
Daniel Martínez‐Carballeira,Ángel Bernardo,Alberto Caro,Inmaculada Soto,Laura Gutiérrez
标识
DOI:10.3390/hematolrep16020021
摘要
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by an isolated decrease in the platelet count and an increased risk of bleeding. The pathogenesis is complex, affecting multiple components of the immune system and causing both peripheral destruction of platelets and impaired central megakaryopoiesis and platelet production in the bone marrow. Here, we intend to contextualize the current knowledge on the pathophysiology, terminology, epidemiology, clinical manifestations, diagnosis, and prognosis of ITP from a historical perspective and the first references to the never-stopping garnering of knowledge about this entity. We highlight the necessity to better understand ITP in order to be able to provide ITP patients with personalized treatment options, improving disease prognosis and reducing the incidence or frequency of refractoriness.
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