Development of a novel human stratum corneum mimetic phospholipid vesicle-based permeation assay models for in vitro permeation studies

OBJECTIVES: permeation studies. SIGNIFICANCE: model containing both SC lipids and proteins was developed. METHODS: in the application of skin penetration. RESULTS: model and porcine ear skin. CONCLUSION: Keratin contained composite phospholipid vesicle-based permeation assay models have been proven to be potential skin tools in topical/transdermal permeation studies.