汤剂
药代动力学
化学
根(腹足类)
异黄酮
色谱法
药理学
口服
串联质谱法
传统医学
液相色谱-质谱法
质谱法
医学
生物化学
类黄酮
植物
生物
抗氧化剂
作者
Hedi Zhao,Miao Qi,Yuan Gong,Han Chen,Dan Wang,Jing Fan,Yanmin Wang,Jingjuan Wang
标识
DOI:10.1002/jssc.202200794
摘要
Danggui Buxue Decoction is a classic formula containing Astragali Radix and Angelicae Sinensis Radix in a 5:1 ratio and has been extensively used to treat blood deficiency for thousands of years. The aim of the study was to investigate the differences in plasma protein binding, pharmacokinetics, and tissue distribution of Danggui Buxue Decoction in normal and blood-deficient rats by ultra-performance liquid chromatography-tandem mass spectrometry. The effects on peripheral blood routine were verified. The compounds exhibited higher plasma protein binding and absorption in the model group compared to the control group, except formononetin. The six ingredients were distributed widely, and the highest concentrations were detected in the heart and uterus. As has been demonstrated in the previous study of the effect of Danggui Buxue Decoction, its potential is to serve as an effective traditional Chinese medicine formula for treating cardiovascular diseases and impacting estrogenic properties, which reveals the potential target organs of Danggui Buxue Decoction the heart and uterus. Our findings suggested that the absorption and distribution of different components in Danggui Buxue Decoction varies depending on the pathological state, molecular weight, lipid solubility, transporter-mediated efflux, and other factors.
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