医学
白藜芦醇
糖尿病
肱动脉
内科学
安慰剂
内皮功能障碍
置信区间
交叉研究
内皮
肾功能
冠状动脉疾病
心脏病学
肾脏疾病
血红蛋白
内分泌学
血压
药理学
病理
替代医学
作者
Colin Gimblet,Nicholas T. Kruse,Katharine Geasland,James D. Michelson,Mingyao Sun,Safur Rehman Mandukhail,Linder Wendt,Patrick Ten Eyck,Gary L. Pierce,Diana Jalal
出处
期刊:Clinical Journal of The American Society of Nephrology
[American Society of Nephrology]
日期:2023-10-16
标识
DOI:10.2215/cjn.0000000000000337
摘要
Patients with CKD and diabetes are at higher risk of developing cardiovascular disease, in part, because of impaired endothelial function. Cardioprotective compounds such as resveratrol could improve endothelial function and attenuate the cardiovascular burden in patients with CKD and diabetes. We hypothesized that resveratrol supplementation would improve endothelial function in patients with CKD and diabetes.Twenty-eight adults aged 68±7 years (84% men) with stage 3 CKD and diabetes were enrolled in a randomized, double-blind, placebo-controlled, crossover study to investigate the effects of 6-week resveratrol supplementation (400 mg/d) on endothelial function. Endothelial function was determined through brachial artery flow-mediated dilation.The mean values for eGFR and hemoglobin A 1c were 40±9 ml/min per 1.73 m 2 and 7.36%±0.72%, respectively. Compared with placebo, resveratrol supplementation increased flow-mediated dilation (ratio of geometric mean changes and 95% confidence interval for between-group comparisons, 1.43 (1.15 to 1.77); P value = 0.001). eGFR, hemoglobin A 1c , BP, and nitroglycerin-mediated dilation were unchanged with resveratrol or placebo ( P = 0.15), suggesting the observed change in flow-mediated dilation was likely independent of changes in traditional cardiovascular risk factors.Resveratrol supplementation improved endothelial function in patients with CKD and diabetes.Resveratrol and Vascular Function in CKD, NCT03597568 .
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