荧光
超氧化物歧化酶
过氧化氢酶
氧化应激
近红外光谱
抗氧化剂
催化作用
化学
生物物理学
Atom(片上系统)
光化学
材料科学
纳米技术
生物化学
生物
物理
量子力学
神经科学
计算机科学
嵌入式系统
作者
Huizhen Ma,Xiaoning Zhang,Ling Liu,Yingwei Huang,Si Sun,Ke Chen,Xiangdong Qi,Pengfei Liu,Yuxing Yan,Yili Wang,Yuan Li,Haile Liu,Rongting Zhao,Kexin Tan,Xinzhu Chen,Xun Yuan,Yonghui Li,Ying Liu,Haitao Dai,Changlong Liu,Hao Wang,Xiao Dong Zhang
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2023-08-04
卷期号:9 (31)
被引量:15
标识
DOI:10.1126/sciadv.adh7828
摘要
Strong fluorescence and high catalytic activities cannot be achieved simultaneously due to conflicts in free electron utilization, resulting in a lack of bioactivity of most near-infrared-II (NIR-II) fluorophores. To circumvent this challenge, we developed atomically precise Au22 clusters with strong NIR-II fluorescence ranging from 950 to 1300 nm exhibiting potent enzyme-mimetic activities through atomic engineering to create active Cu single-atom sites. The developed Au21Cu1 clusters show 18-fold higher antioxidant, 90-fold higher catalase-like, and 3-fold higher superoxide dismutase-like activities than Au22 clusters, with negligible fluorescence loss. Doping with single Cu atoms decreases the bandgap from 1.33 to 1.28 eV by predominant contributions from Cu d states, and Cu with lost electron states effectuates high catalytic activities. The renal clearable clusters can monitor cisplatin-induced renal injury in the 20- to 120-minute window and visualize it in three dimensions using NIR-II light-sheet microscopy. Furthermore, the clusters inhibit oxidative stress and inflammation in the cisplatin-treated mouse model, particularly in the kidneys and brain.
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