Pharmacokinetics of lafutiding tablets in healthy volunteers

OBJECTIVE To study the pharmacokinetics of lafutiding tablets in healthy volunteers.METHODS The plasma concentrations of lafutiding tablets were determined by LC-MS methods after the lafutiding tablets(10㎎) were given to the 12 healthy volunteers.RESULTS tmax was(1.3±0.4) hours.Cmax was(158.6±41.6)μg·L-1,AUC0-24 was(882.0±306.1) μg·h-1·L-1,AUC0-∞was(898.8±316.4) μg·h-1·L-1.The t1/2α of estimate was(1.45±0.14)hours.t1/2β was(4.4±0.4)hours,CL/F was(12.3±4.1) h-1.CONCLUSION The t1/2 、 Cmax、CL/F、AUC0-24and AUC0-∞ about the lafutiding tablets in male healthy volunteers is similar to the female healthy volunteers's(P0.05).tmax is different between female and male(P0.05),the results show that there was no significant difference in pharmacokinetics compared with the reported reference.