Objective:To analysis lesion patterns on DWI in ischemic stroke TOAST subtypes.Methods:262 patients with ischemic stroke,diagnosed by MRI were classfied retrospectively according to TOAST subtype ciriteria.we analysed the characteristics and lesion pattens in different aetiologies of ischemic stroke.Results:The most common underlying stroke subtype,in 75(28.62%) patients was SAA,LAA in 74(28.24%) patients,CE in 32(12.21%) patients,SOU in 40(15.26%) patients,SUE in 41(15.64%) patients.According to lesion patterns on DWI,No lesions on DWI were found in 20(7.61%)patients,mainly in SAA(55%).Single lesion in 130(49.61%) patients were divided into ≥1.5cm in LAA(46.55%),and 1.5cm in SAA(71.62%).Scatted lesions in 69(26.33%)patients were not specific to any one classficationg TOAST Subtypes,beside CE.Multiple lesions in 45(17.17%) patients were in CE and LAA(18.96%,respectively).Conclusions:Lesion patterns based on DWI were helpful for defining aetiology of ischemic stroke.