The surface modification of nano-TiO_2/Ag~+ by grafting KH560 were performed. Effects of reaction conditions such as reaction temperature,reaction time,pH and content of silane coupling agent KH560 on the surface modification of nano-TiO_2/Ag~+ were systematically studied.Scanning Electron Microscope-X-Energy Spectroscopy(SEM-EDS),Transmission Electron Microscope(TEM) and FT-IR spectrums were employed to analyze the surface component and dispersability of the nano-TiO_2/Ag~+ before and after grafting modification.The results show that the optimal modifying condition is as follows: the content of silane coupling agent KH560 is 8 phr,the surface modification temperature is 80℃,the reaction time is 1.5 hour,the pH is 7.KH560 could be chemically bonded on the surface of nano-TiO_2/Ag~+.The dispersability and lipophilic degree of surface modified nano-TiO_2/Ag~+ is better than that of unmodified nano-TiO_2/Ag~+.