Anti-Candida Albicans Activity of Fluconazole in Combination with Ethanol in Vitro

Objective To investigate the anti-Candida albicans activity of fluconzaole combinated with ethanol in vitro.Methods Using minimum concentration of ethanol being not fungistatic,the minimum inhibitory concentration(MICs) of fluconazole alone and in combination with ethanol were determined in 10 C.albicans strains by NCCLS-M27-A microdilution method.Results The MICs of fluconazole alone to C.albicans above were 4-64 μg/ml,while those of fluconazole in combination with 3.75%(v:v) ethanol were 0.125-0.500 μg/ml.Conclusion Ethanol can increase the susceptility of C. albicans to fluconazole.