Towards Selective Inhibitors of Janus Kinase 3: Identification of a Novel Structural Variation between Janus Kinases 2 and 3

E-mail: chongy@konkuk.ac.krReceived August 13, 2012, Accepted September 6, 2012Key Words : Janus kinase 3 (JAK3), Selective inhibitors, Flavonoid conjugate, Structural variationThe mammalian Janus kinase (JAK) family of intracellularnonreceptor protein tyrosine kinases consists of four iso-forms (JAK1, JAK2, JAK3 and TYK2) that play key roles inthe cytokine-mediated JAK-STAT (signal transducer andactivator of transcription) signaling pathway which controlssurvival, proliferation, and differentiation of a variety ofcells.