嘌呤霉素
海马结构
神经科学
英语
海马体
长期记忆
心理学
生物
生物化学
认知
蛋白质生物合成
作者
Josefa B. Flexner,Louis B. Flexner,Eliot Stellar
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1963-07-05
卷期号:141 (3575): 57-59
被引量:471
标识
DOI:10.1126/science.141.3575.57
摘要
The antibiotic, puromycin, caused loss of memory of avoidance discrimination learning in mice when injected intracerebrally. Bilateral injections of puromycin involving the hippocampi and adjacent temporal cortices caused loss of short-term memory; consistent loss of longer-term memory required injections involving, in addition, most of the remaining cortices. Spread of the effective memory trace from the temporal-hippocampal areas to wide areas of the cortices appears to require 3 to 6 days, depending upon the individual animal. Recent reversal learning was lost while longer-term initial learning was retained after bilateral injections into the hippocampal-temporal areas.
科研通智能强力驱动
Strongly Powered by AbleSci AI