化学
Negishi偶联反应
卤化物
碘化物
芳基
锌
钯
铜
联轴节(管道)
组合化学
光化学
有机化学
催化作用
烷基
机械工程
工程类
作者
Edward G. Corley,Kendon J. Conrad,Jerry A. Murry,Cécile Savarin,Justin Holko,Geneviève N. Boice
摘要
A general procedure for the synthesis of 4-arylpiperidines via the coupling of 4-(N-BOC-piperidyl)zinc iodide with aryl halides and triflates is presented. The reaction requires cocatalysis with both Cl2Pd(dppf) and a copper(I) species. An improved, safer procedure for the activation of zinc dust is also presented.
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