医学
肝硬化
细菌易位
高动力循环
合生元
败血症
门脉高压
内科学
免疫学
胃肠病学
益生菌
染色体易位
细菌
遗传学
化学
基因
生物
生物化学
出处
期刊:World Journal of Hepatology
日期:2015-03-27
卷期号:7 (3): 425-425
被引量:121
标识
DOI:10.4254/wjh.v7.i3.425
摘要
A "leaky gut" may be the cutting edge for the passage of toxins, antigens or bacteria into the body, and may play a pathogenic role in advanced liver cirrhosis and its complications. Plasma endotoxin levels have been admitted as a surrogate marker of bacterial translocation and close relations of endotoxemia to hyperdynamic circulation, portal hypertension, renal, cardiac, pulmonary and coagulation disturbances have been reported. Bacterial overgrowth, increased intestinal permeability, failure to inactivate endotoxin, activated innate immunity are all likely to play a role in the pathological states of bacterial translocation. Therapeutic approach by management of the gut-liver axis by antibiotics, probiotics, synbiotics, prebiotics and their combinations may improve the clinical course of cirrhotic patients. Special concern should be paid on anti-endotoxin treatment. Adequate management of the gut-liver axis may be effective for prevention of liver cirrhosis itself by inhibiting the progression of fibrosis.
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