内化
药物输送
细胞
细胞穿透肽
靶向给药
肽
计算生物学
化学
细胞生物学
药物发现
内吞作用
体外
生物物理学
细胞内
生物
细胞膜
脂质体
生物化学
有机化学
作者
Eric Vivès,Julien Schmidt,André Pèlegrin
标识
DOI:10.1016/j.bbcan.2008.03.001
摘要
During the last decade, the potential of peptides for drug delivery into cells has been highlighted by the discovery of several cell-penetrating peptides (CPPs). CPPs are very efficient in delivering various molecules into cells. However, except in some specific cases, their lack of cell specificity remains the major drawback for their clinical development. At the same time, various peptides with specific binding activity for a given cell line (cell-targeting peptides) have also been reported in the literature. One of the goals of the next years will be to optimize the tissue and cell delivery of therapeutic molecules by means of peptides which combine both targeting and internalization advantages. In this review, we describe the main strategies that are currently in use or likely to be employed in the near future to associate both targeting and delivery properties.
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