DC标志
登革热病毒
病毒学
抗体依赖性增强
树突状细胞
生物
病毒
登革热
抗体
转染
血清型
细胞培养
免疫系统
免疫学
遗传学
作者
Boonrat Tassaneetrithep,Timothy H. Burgess,Angela Granelli‐Piperno,Christine Trumpfheller,Jennifer Finke,Wellington Sun,Michael A. Eller,Kovit Pattanapanyasat,S Sarasombath,Deborah L. Birx,Ralph M. Steinman,Sarah J. Schlesinger,Mary Marovich
摘要
Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells. THP-1 cells become susceptible to dengue infection after transfection of DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), or its homologue L-SIGN, whereas the infection of dendritic cells is blocked by anti–DC-SIGN antibodies and not by antibodies to other molecules on these cells. Viruses produced by dendritic cells are infectious for DC-SIGN– and L-SIGN–bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection.
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