聚糖
糖组学
凝集素
分子印迹聚合物
化学
分子识别
分子印迹
糖蛋白
印记(心理学)
生物化学
组合化学
计算生物学
纳米技术
生物
选择性
分子
有机化学
材料科学
基因
催化作用
作者
Zijun Bie,Yang Chen,Ye Jin,Shuangshou Wang,Zhen Liu
标识
DOI:10.1002/anie.201503066
摘要
Lectins possess unique binding properties and are of particular value in molecular recognition. However, lectins suffer from several disadvantages, such as being hard to prepare and showing poor storage stability. Boronate-affinity glycan-oriented surface imprinting was developed as a new strategy for the preparation of lectin-like molecularly imprinted polymers (MIPs). The prepared MIPs could specifically recognize an intact glycoprotein and its characteristic fragments, even within a complex sample matrix. Glycan-imprinted MIPs could thus prove to be powerful tools for important applications such as proteomics, glycomics, and diagnostics.
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