Epidermolysis Bullosa Acquisita

Epidermolysis bullosa acquisita (EBA) is a rare, nonhereditary, blistering disease with clinical features similar to epidermolysis bullosa dystrophica. The clinical features may often simulate porphyria cutanea tarda, pemphigus, or pemphigoid. Three new cases of EBA are discussed. The first patient had signs of a lymphoma-like disorder of lymph nodes. The other two patients had inflammatory disorders of the gastrointestinal tract. A review of all other reported cases of EBA shows a high incidence of associated systemic disease, amyloidosis, colitisenteritis, multiple myeloma, and diabetes mellitus.