Synthesis of 3-Aryl-1,2-dicarba-closo-dodecaboranes by Suzuki-Miyaura Coupling Reaction

In contrast to conventional syntheses of 3-aryl-o-carborane derivatives, which involve reconstruction of the o-carborane cage or Pd-catalyzed coupling reaction of 3-iodo-o-carborane with Grignard reagents, the Suzuzki-Miyaura coupling reaction of 3-iodo-o-carborane proceeds with a variety of aryl boronic acids, providing a new route to 3-aryl-o-carborane derivatives bearing easily transformable functional groups, including CH 3 O-, NO 2 -, CHO- and CN-. This approach provides easy access to a variety of compounds with a 3-aryl-o-carborane scaffold.