医学
脑炎
边缘脑炎
打嗝
共济失调
吞咽困难
恶心
眩晕
呕吐
超液化
胃肠病学
内科学
病理
麻醉
免疫学
外科
病毒
精神科
作者
Sibu Mundiyanapurath,Sven Jarius,Christian Probst,Winfried Stöcker,Brigitte Wildemann,Julian Bösel
标识
DOI:10.1016/j.jneuroim.2013.04.004
摘要
Gamma-aminobutyric-acid B (GABA-B)-receptor encephalitis represents a novel entity among autoimmune CNS disorders. Most cases are characterised by limbic encephalitis.A 63-year-old patient presented with acute vertigo, nausea and vomiting, facial palsy and dysarthria. He developed dysphagia, gait ataxia and, finally, respiratory failure. Antibodies to GABA-B receptors were positive and declined under treatment with intravenous methylprednisolone and plasma exchange, followed by clinical improvement and stabilisation. Broad tumour screening revealed oesophageal carcinoma.The spectrum of neurological manifestations and tumours associated with the paraneoplastic variant of anti-GABA-B-receptor encephalitis may be broader than previously reported.
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