Group cognitive behavioural therapy increases complete remission of obsessive-compulsive disorder symptoms compared with sertraline, but not response

Sousa MB, Isolan LR, Oliveira RR, et al . A randomized clinical trial of cognitive-behavioral group therapy and sertraline in the treatment of obsessive-compulsive disorder. J Clin Psychiatry 2006;67:1133–9.[OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Q What is the efficacy of group cognitive behavioural therapy compared with sertraline for reducing obsessive-compulsive disorder symptoms in adults? ### ![Graphic][5] Design: Randomised controlled trial. ### ![Graphic][6] Allocation: Concealed. ### ![Graphic][7] Blinding: Single blind (assessors blinded). ### ![Graphic][8] Follow up period: Twelve weeks (treatment period only). ### ![Graphic][9] Setting: Outpatient setting in Brazil; March 2002 to December 2003. ### ![Graphic][10] Patients: Fifty six adults (mean 38.5 years) with diagnosed with DSM-IV obsessive-compulsive disorder (OCD; Mini-International Neuropsychiatric Interview – Brazilian version), and a Yale-Brown Obsessive Compulsive Scale (YBOCS) score of ⩾16. Main exclusion criteria: moderate to severe major depression, Beck Depression Inventory score >16, bipolar disorder, severe personality disorder, psychotic disorder, substance related disorder in the previous six months, Tourette’s syndrome, or organic brain disease. ### ![Graphic][11] Intervention: Group cognitive behavioural therapy (CBT; weekly two-hour group session) or sertraline (50 mg/day in the … [1]: {openurl}?query=rft.jtitle%253DThe%2BJournal%2Bof%2Bclinical%2Bpsychiatry%26rft.stitle%253DJ%2BClin%2BPsychiatry%26rft.aulast%253DSousa%26rft.auinit1%253DM.%2BB.%26rft.volume%253D67%26rft.issue%253D7%26rft.spage%253D1133%26rft.epage%253D1139%26rft.atitle%253DA%2Brandomized%2Bclinical%2Btrial%2Bof%2Bcognitive-behavioral%2Bgroup%2Btherapy%2Band%2Bsertraline%2Bin%2Bthe%2Btreatment%2Bof%2Bobsessive-compulsive%2Bdisorder.%26rft_id%253Dinfo%253Adoi%252F10.4088%252FJCP.v67n0717%26rft_id%253Dinfo%253Apmid%252F16889458%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.4088/JCP.v67n0717&link_type=DOI [3]: /lookup/external-ref?access_num=16889458&link_type=MED&atom=%2Febmental%2F10%2F1%2F25.atom [4]: /lookup/external-ref?access_num=000239548300017&link_type=ISI [5]: /embed/inline-graphic-1.gif [6]: /embed/inline-graphic-2.gif [7]: /embed/inline-graphic-3.gif [8]: /embed/inline-graphic-4.gif [9]: /embed/inline-graphic-5.gif [10]: /embed/inline-graphic-6.gif [11]: /embed/inline-graphic-7.gif