骨关节炎
软骨
医学
变性(医学)
关节软骨
基础科学
关节病
基质骨
发病机制
细胞外基质
病理
解剖
细胞生物学
神经科学
生物
替代医学
作者
Andrew D. Pearle,Russell F. Warren,Scott A. Rodeo
标识
DOI:10.1016/j.csm.2004.08.007
摘要
Articular cartilage is a specialized tissue uniquely suited for load distribution with a low-friction articulating surface. Its compressive and tensile properties are determined by its matrix and fluid composition, and are maintained by chondrocytes in the homeostatic joint. Osteoarthritis (OA) is increasingly understood as a family of disorders in which the biomechanical properties of cartilage are altered and ultimately fail as the tissue is degraded by local proteases. Mechanically mediated and cytokine-mediated pathways of cartilage degeneration have been identified in the pathogenesis of OA. Further insight into the basic science of cartilage and OA is necessary to develop diagnostic and treatment strategies for this pervasive disease.
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