鱼腥草
化学
传统医学
消炎药
生物碱
生药学
IC50型
立体化学
体外
生物活性
生物化学
药理学
色谱法
生物
萃取(化学)
医学
作者
Jongmin Ahn,Hee‐Sung Chae,Young‐Won Chin,Jinwoong Kim
标识
DOI:10.1016/j.bmcl.2017.04.072
摘要
New alkaloids, houttuynamide B and C (1, 2) and houttuycorine (14), were isolated from the aerial parts of Houttuynia cordata Thunb. in addition to eighteen known alkaloids. Their structures were elucidated through extensive spectroscopic analysis. All the isolates were tested for their inhibitory activity against NO production in RAW 264.7 cells stimulated by LPS. Of the tested compounds, compound 15 showed the most potent anti-inflammatory activity with an IC50 value of 8.7 μM.
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