Liver X Receptors (LXRs) – Important Regulators of Lipid Homeostasis

Introduction Nuclear Hormone Receptors The Liver X Receptors, LXRα; and LXRβ The Cholesterol Sensor: LXR Interplay between Cholesterol and Fatty Acid Metabolism LXR and SREBP-1c Activation: a New Link between Cholesterol and Fatty Acid Regulation Direct Regulation of Target Genes by LXRs in Lipid Metabolism LXRs as Insulin Sensors in Liver Fatty Acid Regulation of LXR LXRs in Adipose Tissue Summary Acknowledgements References